Document ID (ISN) | 68751 |
CIS number |
97-548 |
ISSN - Serial title |
0025-7818 - Medicina del lavoro |
Year |
1994 |
Convention or series no. |
|
Author(s) |
Manno M., Saia B. |
Title |
Biotransformation in occupational medicine: The role of liver cytochrome P-450 in the mechanism of action and biological monitoring of occupational toxic substances |
Original title |
La biotrasformazione in medicina del lavoro: ruolo del citocromo P-450 epatico nel meccanismo d'azione e nel monitoraggio biologico dei tossici occupazionali [in Italian] |
Bibliographic information |
Jan.-Feb. 1994, Vol.85, No.1, p.11-21. Illus. 19 ref. |
Abstract |
Review of the important enzyme system involved in the biotransformation of industrial chemicals: cytochrome P-450. The study of the various metabolic reactions of this peculiar group of enzymes has contributed to a) the clarification of the mode of action of toxic and/or carcinogenic substances present in the work environment, such as aromatic amines, polycyclic aromatic hydrocarbons, halogenated alkanes, benzene compounds etc.; and b) the improvement of risk assessment in the biological monitoring of exposed workers. |
Descriptors (primary) |
carcinogens; cytochrome oxidase; exposure tests; toxic metabolites; hazard evaluation; toxic substances |
Descriptors (secondary) |
metabolic process |
Document type |
D - Periodical articles |
Country / State or Province | Italy |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Risk evaluation Biological monitoring
|