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Document ID (ISN)68587
CIS number 97-558
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1996
Convention or series no.
Author(s) Simpson C., Garabrant D., Torrey S., Robins T., Franzblau A.
Title Hypersensitivity pneumonitis-like reaction and occupational asthma associated with 1,3-bis(isocyanatomethyl) cyclohexane pre-polymer
Bibliographic information July 1996, Vol.30, No.1, p.48-55. 26 ref.
Abstract Twenty three of 34 workers who had worked in the injection moulding operation making polyurethane foam parts at an automobile manufacturing plant developed respiratory symptoms and/or systemic symptoms over a 2-month period following the full production use of a new diisocyanate paint that contained 1,3-bis(isocyanatomethyl)cyclohexane pre-polymer (BIC). At 3 months, all subjects underwent an interview, physical examination, pre- and post-shift pulmonary function tests and either methacholine challenge test or bronchodilator challenge. The most frequently cited symptoms were dyspnoea, cough, chest tightness, chills, wheezing and myalgias, arthralgias and nausea. Thirteen subjects had either a positive methacholine challenge test or a positive response to bronchodilator challenge, making the overall prevalence of airway hyperresponsiveness 38%. The overall prevalence of hypersensitivity pneumonitis-like reactions among line operators in the injection moulding process was 27%. The results suggest that BIC may cause asthma and hypersensitivity pneumonitis-like reactions.
Descriptors (primary) isocyanates; asthma; hypersensitivity; motor vehicle industry; respiratory diseases
Descriptors (secondary) polyurethane; methacholine; bronchodilators; respiratory function tests; bronchopulmonary diseases; cohort study; paints
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Cyano compounds
Motor vehicle manufacturing industry