| Document ID (ISN) | 68540 |
| CIS number |
97-180 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1995 |
| Convention or series no. |
|
| Author(s) |
Ong C.N., Kok P.W., Lee B.L., Shi C.Y, Ong H.Y., Chia K.S., Lee C.S., Luo X.W. |
| Title |
Evaluation of biomarkers for occupational exposure to benzene |
| Bibliographic information |
Aug. 1995, Vol.52, No.8, p.528-533. 26 ref. |
| Abstract |
In order to evaluate the relations between environmental benzene concentrations and various biomarkers of exposure to benzene, analyses were carried out on environmental air, unmetabolized benzene in urine, trans,trans-muconic acid (ttMA) and three major phenolic metabolites of benzene (catechol, hydroquinone and phenol) in two field studies on 64 workers exposed to benzene. Forty non-exposed subjects were also investigated. Among the five urinary biomarkers studied, ttMA correlated best with environmental benzene concentration. The results from the study showed that both ttMA and hydroquinone were able to differentiate the background level found in subjects not occupationally exposed and those exposed to less than 1ppm of benzene. This suggests that these two biomarkers are useful indices for monitoring low concentrations of benzene. The good correlations between ttMA, hydroquinone and atmospheric benzene suggest that they are sensitive and specific biomarkers for benzene exposure. |
| Descriptors (primary) |
leukaemogenic effects; metabolic process; benzene; biological and medical tests; environmental pollution; exposure tests; hazard evaluation |
| Descriptors (secondary) |
phenol; pyrocatechol; comparative study; hydroquinone; urine monitoring |
| Document type |
D - Periodical articles |
| Country / State or Province | Singapore |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Aromatic hydrocarbons
Leukaemia
Environmental pollution
Risk evaluation
Biological monitoring
|
