ILO Home
Go to the home page
Site map | Contact us Français | Español

CISDOC database

Document ID (ISN)68537
CIS number 97-188
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1995
Convention or series no.
Author(s) Kim Y., Harada K., Ohmori S., Lee B.K., Miura H., Ueda A.
Title Evaluation of lead exposure in workers at a lead-acid battery factory in Korea: With focus on activity of erythrocyte pyrimidine 5'-nucleotidase (P5N)
Bibliographic information July 1995, Vol.52, No.7, p.484-488. 29 ref.
Abstract Activity of erythrocyte pyrimidine 5'-nucleotidase (P5N) and other biological variables were examined in 66 exposed workers in a lead-acid battery factory and in 26 non-exposed workers in Korea. The time-weighted average of 13 of 18 air samples for lead exceeded 0.05mg/m3. Blood lead concentration (PbB) in 39 of the 66 exposed workers was above 40µg/dL and the mean PbB in the exposed group was 45.7(15,7)µg/dL. Compared with the non-exposed group, erythrocyte P5N activity and activity of erythrocyte aminolevulinic-acid dehydratase (ALAD) were significantly inhibited. The findings show that the depression of erythrocyte P5N activity by lead exposure results in the accumulation of erythrocyte pyrimidine nucleotides. The results indicate that the erythrocyte P5N activity test provides supporting evidence of lead exposure and shows the effect of lead on nucleotide metabolism.
Descriptors (primary) pyrimidine nucleotidase; lead; biological effects; exposure evaluation; battery and dry cell manufacture; enzyme activity
Descriptors (secondary) nucleotides; enzyme inhibition; Korea, Republic of; ALAD; comparative study; case-control study; metabolic studies; exposure tests; storage batteries
Document type D - Periodical articles
Country / State or ProvinceJapan; Korea, Republic of
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Exposure evaluation
Manufacturing of electrical appliances and equipment
Lead and compounds
Inorganic substances