|Document ID (ISN)||68533|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Nishijo M., Nakagawa H., Morikawa Y., Tabata M., Senma M., Miura K., Takahara H., Kawano S., Nishi M., Mizukoshi K., Kido T., Nogawa K.
||Mortality of inhabitants in an area polluted by cadmium: 15 year follow-up
||Mar. 1995, Vol.52, No.3, p.181-184. 22 ref.
||Follow-up study for 15 years (from 1974-5 to 1991) carried out on 2408 inhabitants of the Kakehashi River basin in Ishikawa Prefecture, Japan. The inhabitants had been the subjects of the health impact survey in 1974-5 to evaluate (by measurement of urinary retinol binding protein (RBP)) renal dysfunction induced by cadmium. Analysis of mortality was performed by dividing subjects into a urinary RBP positive group and RBP negative group. After adjustment for age, RBP positive group showed a significant relation to mortality in both sexes. When the standardized mortality ratios according to causes of deaths in the RBP positive group were compared with those of the RBP negative group or the overall Japanese population, increases of this ratio for cardiovascular diseased, especially heart failure, and renal diseases were found in both sexes. The results suggest that the prognosis of the exposed inhabitants with renal tubular dysfunction is unfavourable and the increase of mortality is due to heart failure and renal diseases.
||Japan; renal dysfunction; cardiovascular diseases; environmental pollution; cadmium; mortality
||prognosis; long-term study; comparative study; urine cytology; sex-linked differences
||D - Periodical articles
|Country / State or Province||Japan|
||Toxic and dangerous substances
|Broad subject area(s)
Diseases of the kidney and the urinary system
Cadmium and compounds