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CISDOC database

Document ID (ISN)68375
CIS number 97-170
ISSN - Serial title 0091-6765 - Environmental Health Perspectives
Year 1996
Convention or series no.
Author(s) Todd A.C., Wetmur J.G., Moline J.M., Godbold J.H., Levin S.M., Landrigan P.J.
Title Unraveling the chronic toxicity of lead: An essential priority for environmental health
Bibliographic information Mar. 1996, Vol.104, Suppl.1, p.141-146. 68 ref.
Abstract Exposure to lead in the general population has declined, but chronic lead toxicity remains a major public health problem in the United States, affecting millions of children and adults. To close current gaps in knowledge of chronic lead toxicity an integrated, multidisciplinary, marker-based research programme combines a) direct measurement of individual lead burden by Cd-109 X-ray fluorescence analysis of lead in bone, b) determination of ALA-D phenotype as index of individual susceptibility to lead, and c) assessments of subclinical injury produced by lead in the kidneys, nervous system and the reproductive organs. This marker-based research program offers a feasible approach to understand the following questions: a) are current environmental and occupational standards adequate to prevent chronic lead intoxication? b) is lead mobilized from the skeleton during pregnancy or lactation to cause foetal toxicity? c) is lead mobilized from bone during menopause to cause neurotoxicity? d) what is the significance of genetic variation in determining susceptibility to lead? e) what is the contribution of lead to hypertension, renal disease, chronic neurodegenerative disease or declining sperm counts? f) is chelation therapy effective in reducing body lead burden in persons with chronic overexposure to lead?
Descriptors (primary) neurotoxic effects; antifertility effects; nephrotoxic effects; lead; ALAD; hypertension
Descriptors (secondary) medical supervision; literature survey
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Cardiovascular diseases
Diseases of the nervous system
Lead and compounds
Genetic factors in reaction to exposures
Inorganic substances
Antifertility and prenatal effects