| Document ID (ISN) | 68040 |
| CIS number |
96-2200 |
| ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
| Year |
1993 |
| Convention or series no. |
|
| Author(s) |
Persson P., Dalene M., Skarping G., Adamsson M., Hagmar L. |
| Title |
Biological monitoring of occupational exposure to toluene diisocyanate: Measurement of toluenediamine in hydrolysed urine and plasma by gas chromatography-mass spectrometry |
| Bibliographic information |
Dec. 1993, Vol.50, No.12, p.1111-1118. Illus. 22 ref. |
| Abstract |
Exposure to toluene diisocyanate (TDI) was studied during 48 hours and biological samples were taken in a factory producing flexible polyurethane (PUR) foam. Five PUR workers, two white-collar workers and two volunteers were studied. The concentrations of TDI in air were determined by high-performance liquid chromatography. Urine and plasma samples were collected, and TDI-related amines, 2,4-toluenediamine (2,4-DTA) and 2,6-toluenediamine (2,6-TDA) were determined by capillary gas chromatography and mass spectrometry. The environmental concentration of TDI was within the range of 1-10% of the Swedish TLV (40mg/m3). The relationship between 2,4-TDI and 2,6-TDI varied in atmospheric samples from 3:2 to 1:19. The PUR workers showed TDA plasma concentrations in the range of 1-8ng/mL, significantly higher than the concentration of 0.2-1ng TDA/mL plasma seen in the white-collar workers only rarely exposed to TDI. The concentration of 2,4-TDA and 2,6-TDA in PUR workers' plasma was stable. No relationship could be established between urinary excretion and TDA plasma concentration. It seems to be possible therefore to monitor TDI exposure by measuring TDA plasma concentration. |
| Descriptors (primary) |
diaminotoluenes; exposure tests; determination in biological matter; tolylene diisocyanate |
| Descriptors (secondary) |
mass spectrometry; 2,4-tolylene diisocyanate; exposure evaluation; comparative study; gas chromatography; determination in urine; determination in blood |
| Document type |
D - Periodical articles |
| Country / State or Province | Sweden |
| Subject(s) |
Chemicals, plastics and rubber
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Aromatic amines
Biological monitoring
Isocyanates
Cyano compounds
|
