| Document ID (ISN) | 68035 |
| CIS number |
96-2198 |
| ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
| Year |
1993 |
| Convention or series no. |
|
| Author(s) |
van Sittert N.J., Boogaard P.J., Beulink G.D.J. |
| Title |
Application of the urinary S-phenylmercapturic acid test as a biomarker for low levels of exposure to benzene in industry |
| Bibliographic information |
May 1993, vol.50, No.5, p.460-469. Illus. 20 ref. |
| Abstract |
Recently, the determination of S-phenylmercapturic acid (S-PMA) in urine has been proposed as a suitable biomarker for the monitoring of low-level exposures to benzene. In the study reported here, the test was validated in 12 separate studies in chemical manufacturing plants, oil refineries and natural gas production plants. A strong correlation was found between eight hour exposure to airborne benzene of 1mg/m3 (0.3ppm) and higher and urinary S-PMA concentrations in end-of-shift samples. A strong correlation was also found between urinary phenol and S-PMA concentrations. In conclusion, with the current sensitivity of the test, eight hour time-weighted-average benzene exposures of 1mg/m3 (0.3ppm) and higher can be measured. |
| Descriptors (primary) |
S-phenylmercapturic acid; chemical industry; benzene; determination in urine; petroleum and natural gas industry; petroleum refining; exposure tests; urinary metabolites |
| Descriptors (secondary) |
urinary excretion; comparative study; urine monitoring; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | Netherlands |
| Subject(s) |
Chemicals, plastics and rubber
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Petroleum and natural gas industry
Chemical industry
Biological monitoring
Aromatic hydrocarbons
Petrochemical industry
|
