ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)67892
CIS number 96-2303
ISSN - Serial title 0394-2953 - Archivio di Scienze del Lavoro
Year 1995
Convention or series no.
Author(s) Romano C., De Luca G.
Title Protection of workers exposed to biological agents. Study on the prevention of hepatitis B by means of vaccination in a cohort of such workers. Consideration after a 5-year follow-up
Original title Protezione dei lavoratori dagli agenti biologici. Una esperienza di vaccinoprofilassi contro l'epatite B in una popolazione di professionalmente esposti a rischio. Considerazioni dopo 5 anni di follow-up [in Italian]
Bibliographic information Jan.-Mar. 1995, Vol.11, No.1, p.17-21. 20 ref.
Abstract The results are reported of a cohort study conducted for 5 years in 82 workers exposed to biological hazards (manipulation of sera in a pharmaceutical plant). The workers were vaccinated at scheduled intervals (three doses) against hepatitis B. The effectiveness of their immunization was repeatedly checked in subsequent years by means of an anti-HBs titre assay. In 96.3% of the subjects the result of the assay was positive (HBsAb >10mUI/mL serum level, i.e. the generally accepted cut-off value for a specific positive response). Only three subjects (3.66%) showed no response. To protect these workers, a further administration of vaccine is proposed by some experts. Booster doses 1-2 months after the third dose of vaccine are suggested for workers with anti-HB titres below 10mUI/mL, in order to prolong their immunity against HBV. Repeated serum controls are recommended for all workers every 4-5 years.
Descriptors (primary) infectious hepatitis; vaccination; immunization; pharmaceutical industry
Descriptors (secondary) cohort study; biological hazards; long-term study
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Occupational pathology
Broad subject area(s) Biological hazards
Browse category(ies) Liver diseases
Pharmaceutical industry
Bacterial and parasitic diseases
Viral diseases (other than aids)