|Document ID (ISN)||67892|
|ISSN - Serial title
||0394-2953 - Archivio di Scienze del Lavoro
|Convention or series no.
||Romano C., De Luca G.
||Protection of workers exposed to biological agents. Study on the prevention of hepatitis B by means of vaccination in a cohort of such workers. Consideration after a 5-year follow-up
||Protezione dei lavoratori dagli agenti biologici. Una esperienza di vaccinoprofilassi contro l'epatite B in una popolazione di professionalmente esposti a rischio. Considerazioni dopo 5 anni di follow-up [in Italian]|
||Jan.-Mar. 1995, Vol.11, No.1, p.17-21. 20 ref.
||The results are reported of a cohort study conducted for 5 years in 82 workers exposed to biological hazards (manipulation of sera in a pharmaceutical plant). The workers were vaccinated at scheduled intervals (three doses) against hepatitis B. The effectiveness of their immunization was repeatedly checked in subsequent years by means of an anti-HBs titre assay. In 96.3% of the subjects the result of the assay was positive (HBsAb >10mUI/mL serum level, i.e. the generally accepted cut-off value for a specific positive response). Only three subjects (3.66%) showed no response. To protect these workers, a further administration of vaccine is proposed by some experts. Booster doses 1-2 months after the third dose of vaccine are suggested for workers with anti-HB titres below 10mUI/mL, in order to prolong their immunity against HBV. Repeated serum controls are recommended for all workers every 4-5 years.
||infectious hepatitis; vaccination; immunization; pharmaceutical industry
||cohort study; biological hazards; long-term study
||D - Periodical articles
|Country / State or Province||Italy|
|Broad subject area(s)
Bacterial and parasitic diseases
Viral diseases (other than aids)