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CISDOC database

Document ID (ISN)67347
CIS number 96-1386
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1995
Convention or series no.
Author(s) Kumagai S., Matsunaga I.
Title Effect of variation of exposure to airborne chlorobenzene on internal exposure and concentration of urinary metabolite
Bibliographic information Jan. 1995, Vol.52, No.1, p.65-70. Illus. 25 ref.
Abstract This study aimed to develop a physiologically based pharmacokinetic model for chlorobenzene and to investigate the effect of variation in exposure to chlorobenzene on the chlorobenzene concentration in blood and the urinary concentration of 4-chlorocatechol. The comparison of the simulated results with the observed data showed that the pharmacokinetic model can be used to estimate the urinary concentrations of 4-chlorocatechol. To protect workers from the chronic effect of chlorobenzene, it may be sufficient to control the daily average exposure. To protect from the acute effect, however, the short term exposure must be controlled as well. The values of 4-chlorocatechol excreted during the last 4 hours (CC(4-8)) and 2 hours (CC(6-8)) were acceptable for estimating daily average exposure, but that excreted during two hours on the next morning (CC(22-24)) was not.
Descriptors (primary) chlorobenzene; exposure evaluation; urine monitoring; mathematical simulation; exposure tests; biological hazards
Descriptors (secondary) toxic effects; comparative study; field tests; urinary metabolites
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Halogenated hydrocarbons
Biological hazards
Exposure evaluation