| Document ID (ISN) | 67346 |
| CIS number |
96-1385 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1995 |
| Convention or series no. |
|
| Author(s) |
London L., Thompson M.L., Sacks S., Fuller B., Bachmann O.M., Myers J.E. |
| Title |
Repeatability and validity of a field kit for estimation of cholinesterase in whole blood |
| Bibliographic information |
Jan. 1995, Vol.52, No.1, p.57-64. Illus. 29 ref. |
| Abstract |
This study evaluated a spectrophotometric field kit (Test-Mate-OP) for repeatability and validity in comparison with reference laboratory methods and to model its anticipated sensitivity and specificity based on these findings. Some 76 farm workers between the age of 20 and 55, of whom 30 were pesticide applicators exposed to a range of organophosphates in the preceding 10 days, had blood taken for plasma cholinesterase (PCE) and erythrocyte cholinesterase (ECE) measurement by field kit or laboratory methods. Field kit repeatability for PCE was much poorer and for ECE slightly poorer than that of laboratory measures. Field kit ECE estimation seems to be sufficiently repeatable for surveillance activities, whereas PCE does not. Repeatability of both tests seems to be too low for use in epidemiological dose-response investigations. |
| Descriptors (primary) |
cholinesterase monitoring; cholinesterase; pesticides; enzymological tests; reliability; exposure evaluation; crop protection |
| Descriptors (secondary) |
organophosphorus compounds; evaluation of technique; field tests; comparative study; determination in blood; spectrophotometry; dose-response relationship |
| Document type |
D - Periodical articles |
| Country / State or Province | South Africa |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Agricultural chemicals
Exposure evaluation
Biological monitoring
|
