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Document ID (ISN)67343
CIS number 96-1389
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1995
Convention or series no.
Author(s) Enterline P.E., Day R., Marsh G.M.
Title Cancers related to exposure to arsenic at a copper smelter
Bibliographic information Jan. 1995, Vol.52, No.1, p.28-32. Illus. 26 ref.
Abstract To verify earlier findings of a supralinear dose response relation between exposure to arsenic in air and deaths from respiratory cancer, and to examine relations with other cancers, an earlier study of 2,802 men who worked at a copper smelter for a year or more during the period 1940-64 and who were followed up for deaths during the period 1941-76 was updated until 1986. Estimates of exposure for the period 1977-1984 were added. The additional follow-up confirms the earlier finding that at low doses the increments in death rates for respiratory cancer for a given increment in dose are greater than at high doses. The additional follow-up also shows significant increases in cancer of the large intestine and bone, and SMRs >150 for cancer of the buccal cavity, pharynx, rectum and kidney. There was a positive relation between exposure to airborne arsenic and kidney and bone cancer, but none for the other cancers (except respiratory cancer).
Descriptors (primary) copper; arsenic; smelting plants; cancer; carcinogenic effects; mortality
Descriptors (secondary) renal cancer; pharyngeal cancer; lung cancer; dose-response relationship; osteosarcoma; cohort study; gastrointestinal cancer
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Smelting and refining operations
Copper and compounds
Arsenic and compounds