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Document ID (ISN)67341
CIS number 96-1384
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1995
Convention or series no.
Author(s) Lee B.K., Schwartz B.S., Stewart W., Ahn K.D.
Title Provocative chelation with DMSA and EDTA: Evidence for differential access to lead storage sites
Bibliographic information Jan. 1995, Vol.52, No.1, p.13-19. Illus. 35 ref.
Abstract This study was designed to validate a provocative chelation test with 2,3-dimercaptosuccinic acid (DMSA) by direct comparison with the standard ethylene diamine tetraacetic acid (EDTA) test in the same subjects and to compare and contrast the predictors of lead excretion after DMSA with those after EDTA. 34 male lead workers in the Republic of Korea were given a single oral dose of 10mg/kg DMSA, urine was collected over the next eight to 24 hours, and urine volume and urinary lead concentration determined at given intervals. Either two weeks before or two weeks after the dose of DMSA, 17 of these workers also received 1g intravenous EDTA followed by an eight hour urine collection with fractionation at set intervals. The predictors of lead excretion after DMSA and EDTA are different and an earlier dose of EDTA may increase lead excretion after a subsequent dose of DMSA. Two-hour or four-hour cumulative lead excretion after DMSA may provide an estimate of lead in storage sites that is most directly relevant to the health effects of lead.
Descriptors (primary) toxic effects; lead; lead industry; EDTA; provocative chelation; dimercaptosuccinic acid
Descriptors (secondary) aminolevulinic acid; urinary excretion; comparative study; determination in blood; human experiments
Document type D - Periodical articles
Country / State or ProvinceKorea, Republic of; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Smelting and refining operations
Lead and compounds