| Document ID (ISN) | 66927 |
| CIS number |
96-812 |
| ISSN - Serial title |
1120-2971 - Prevenzione oggi |
| Year |
1994 |
| Convention or series no. |
|
| Author(s) |
Scassellati Sforzolini G., Moretti M., Villarini M., Angeli G., Pasquini R., Monarca S., Scarselli R., Crea M.G., Leonardis C. |
| Title |
An evaluation of toxic and genotoxic risk from work-related exposure to chemical compounds |
| Original title |
Valutazione del rischio tossico e genotossico da eposizione professionale a composti chimici [in Italian] |
| Bibliographic information |
Oct.-Dec. 1994, Vol.6, N°4, p.125-138. Illus. 45 ref. |
| Abstract |
A series of investigations was conducted to test the genotoxic and enzyme-inducing activity of deltamethrin (decamethrin), in order to contribute to its risk assessment in occupational exposure to pesticides. Using in-vitro methods, its mutagenic activity was tested on procaryotic cells (Ames test) and eucaryotic cells (cytogenetic tests, DNA damage). With in-vivo experiments on rats, various enzyme activities were determined to investigate the capability of deltamethrin to act as "co-mutating/co-cancerogenous" agent and/or "promoter" of carcinogenic processes. The results allow to state that pure deltamethrin, while negative in the Ames test, is capable of damaging the DNA and increasing the frequency of micronuclei in human lymphocytes, requiring therefore the monitoring of such an indicator in the exposed workers. Both the pure and commercial product are able to alter cell metabolism in various ways, with a potential "indirect" genotoxic risk. |
| Descriptors (primary) |
mutagenic effects; decamethrin; carcinogenic effects; genetic effects; pesticides |
| Descriptors (secondary) |
|
| Document type |
D - Periodical articles |
| Country / State or Province | Italy |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Esters and salts
|
