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CISDOC database

Document ID (ISN)66813
CIS number 96-625
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1993
Convention or series no.
Author(s) Dodson R.F., O'Sullivan M., Corn C.J., Garcia J.G.N., Stocks J.M., Griffith D.E.
Title Analysis of ferruginous bodies in bronchoalveolar lavage from foundry workers
Bibliographic information Nov. 1993, Vol.50, No.11, p.1032-1038. Illus. 24 ref.
Internet access 96-0625.pdf [in English]
Abstract Classical ferruginous bodies in tissue samples are considered to be markers of past exposure to asbestos. Recent studies have shown that the presence of ferruginous bodies in bronchoalveolar lavage (BAL) fluid correlates with past exposure to asbestos and offers a more sensitive reference than occupational history. Lavage samples from five subjects who had worked in foundries were evaluated by light microscopy for the presence of ferruginous bodies and by transmission electron microscopy for both characterization of the uncoated fibre burden and analysis of the cores of the ferruginous bodies. All samples at lower magnification (light microscopy (200 x)) contained ferruginous bodies. At higher magnification (400 x), a separate population from this group could be identified by the presence of a thin black ribbon. Transmission electron microscopy of the core materials of ferruginous bodies and comparable uncoated particulates supported the reliability of higher magnification light microscopy for distinguishing most of these non-asbestos cores.
Descriptors (primary) asbestos; ferruginous bodies; bronchopulmonary lavage; exposure tests; foundries; diagnosis
Descriptors (secondary) pulmonary fibrosis; asbestosis; asbestos bodies; comparative study; transmission electron microscopy; light microscopy; bronchoscopy; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Foundries, metalcasting and forging operations
Biological monitoring