ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)66637
CIS number 96-787
ISSN - Serial title 0273-2300 - Regulatory Toxicology and Pharmacology
Year 1994
Convention or series no.
Author(s) Viren J.R., Silvers A.
Title Unit risk estimates for airborne arsenic exposure: An updated view based on recent data from two copper smelter cohorts
Bibliographic information Oct. 1994, Vol.20, No.2, p.125-138. Illus. 20 ref.
Abstract The current unit risk for chronic lifetime exposure to airborne arsenic 4.29 x 10-3, was established by the US EPA in 1984. Using updated results from a cohort mortality study on Tacoma, Washington, smelter workers and recent findings from a cohort study of 3619 Swedish smelter workers, new unit risk estimates were developed for the respective cohorts. Methods were analogous to those used by the EPA in 1984, and all estimates were derived under an absolute risk model. A new unit risk 1.28 x 10-3, was estimated for the Tacoma smelter cohort which was a factor of five less than the EPA's earlier estimate, and a direct result of radically revised exposure estimates. A unit risk of 0.89 x 10-3 was estimated from the Swedish study. Pooling these new risk estimates with the EPA's earlier estimates yielded a composite unit risk of 1.43 x 10-3. Based on this estimate, the present unit risk may overestimate the effects of airborne arsenic by a factor of 3.
Descriptors (primary) airborne dust; arsenic; long-term exposure; exposure evaluation; permissible levels
Descriptors (secondary) Sweden; USA; lung cancer; Washington; determination of exposure limits; smelting plants; cohort study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Exposure evaluation
Arsenic and compounds
Inorganic substances
Occupational exposure limits