|Document ID (ISN)||66439|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Chia K.S., Jeyaratnam J., Lee J., Tan C., Ong H.Y., Lee E.
||Lead-induced nephropathy: Relationship between various biological exposure indices and early markers of nephrotoxicity
||June 1995, Vol.27, No.6, p.883-895. 37 ref.
||Current blood lead levels were determined in 128 lead-exposed workers and in 93 non-exposed controls. For the exposed workers, time-integrated blood indices were derived from serial blood lead measurements taken during the years of exposure. Urinary α1-microglobulin, urinary β2-microglobulin and urinary retinol-binding protein were also measured as markers of lead-induced kidney damage. In the exposed workers, all the effect markers had better correlation with the time-integrated blood lead indices than with current blood lead levels; urinary α1-microglobulin was the only marker that was significantly higher in the exposed group, with a good dose-response and dose-effect relationship with the time-integrated blood lead indices.
||lead; exposure tests; nephrotoxic effects; renal damage
||dose-response relationship; urine monitoring; blood monitoring
||D - Periodical articles
|Country / State or Province||Singapore|
|Broad subject area(s)
||Diseases of the kidney and the urinary system
Lead and compounds