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CISDOC database

Document ID (ISN)66439
CIS number 96-831
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1995
Convention or series no.
Author(s) Chia K.S., Jeyaratnam J., Lee J., Tan C., Ong H.Y., Lee E.
Title Lead-induced nephropathy: Relationship between various biological exposure indices and early markers of nephrotoxicity
Bibliographic information June 1995, Vol.27, No.6, p.883-895. 37 ref.
Abstract Current blood lead levels were determined in 128 lead-exposed workers and in 93 non-exposed controls. For the exposed workers, time-integrated blood indices were derived from serial blood lead measurements taken during the years of exposure. Urinary α1-microglobulin, urinary β2-microglobulin and urinary retinol-binding protein were also measured as markers of lead-induced kidney damage. In the exposed workers, all the effect markers had better correlation with the time-integrated blood lead indices than with current blood lead levels; urinary α1-microglobulin was the only marker that was significantly higher in the exposed group, with a good dose-response and dose-effect relationship with the time-integrated blood lead indices.
Descriptors (primary) lead; exposure tests; nephrotoxic effects; renal damage
Descriptors (secondary) dose-response relationship; urine monitoring; blood monitoring
Document type D - Periodical articles
Country / State or ProvinceSingapore
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the kidney and the urinary system
Lead and compounds
Inorganic substances
Biological monitoring