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Document ID (ISN)65750
CIS number 95-2158
ISSN - Serial title 0091-6765 - Environmental Health Perspectives
Year 1994
Convention or series no.
Author(s) Frenkel K., Karkoszka J., Cohen B., Barański B., Jakubowski M., Cosma G., Taioli E., Toniolo P.
Title Occupational exposures to Cd, Ni, and Cr modulate titers of antioxidized DNA base autoantibodies
Bibliographic information Sep. 1994, Vol.102, Suppl.3, p.221-225. Illus. 16 ref.
Abstract The study determined whether occupational exposures to derivatives of carcinogenic metals evoke inflammatory immune responses, as determined by the presence of elevated titres of antibodies (Ab) that recognize oxidized DNA bases. The oxidized thymidine [5-hydroxymethyl-2'-deoxyuridine (HMdU)] coupled to bovine serum albumin was used as an antigen. Titres of anti-HMdU Ab were significantly elevated in the high cadmium (Cd) and nickel (Ni) exposure groups (18.3 ▒ 3.2 vs. 10.8 ▒ 2.1 A492/ÁL). The Ab titres present in the sera of controls for Cd and Ni exposures appear to be constant regardless of the protein content. In contrast, both lightly and heavily exposed subjects exhibited Ab titres that increased with increasing protein content. The anti-HMdU titres of 12 workers wearing personal monitors showed a significant difference between the groups with light and heavy exposures to Cd (9.8 ▒ 3.7 vs. 22.1 ▒ 3.7 A492/ÁL) and Ni (11.7 ▒ 1.4 vs. 31.0 ▒ 1.8)
Descriptors (primary) cadmium and compounds; carcinogens; nickel and compounds; oxidation; chromium and compounds; exposure; autoimmunization
Descriptors (secondary) antigens; DNA; welding fumes; antibodies; autoantibodies; thymidine
Document type D - Periodical articles
Country / State or ProvincePoland; USA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Nickel and compounds
Cadmium and compounds