| Document ID (ISN) | 65746 |
| CIS number |
95-2144 |
| ISSN - Serial title |
1040-8444 - Critical Reviews in Toxicology |
| Year |
1994 |
| Convention or series no. |
|
| Author(s) |
Coggon D. |
| Title |
Epidemiological studies of styrene-exposed populations |
| Bibliographic information |
Oct. 1994, Vol.24, Suppl., p.S107-S115. 21 ref. |
| Abstract |
Several cohort studies of occupationally exposed populations have suggested that workers exposed to styrene in the chemical industry have increased mortality from lymphatic and haematopoietic cancer. However, this finding has not been consistent and has not been reproduced in studies of reinforced plastics manufacturers, whose exposures to styrene are generally higher. The explanation for the observed associations may therefore be confounding by concomitant exposures to other chemicals such as benzene and butadiene, which are not used in the reinforced plastics industry. Despite their large size, the published studies of mortality and cancer incidence lack the statistical power to rule out an important hazard from long-term exposure to high (>50ppm) airborne concentrations of styrene. However, they indicate that any risk of cancer from lower levels of exposure is likely to be small. |
| Descriptors (primary) |
leukaemia; styrene; exposure; mortality; cancer; lymphoma |
| Descriptors (secondary) |
literature survey; chemical industry; plastics industry; cohort study; long-term exposure; inhalation |
| Document type |
D - Periodical articles |
| Country / State or Province | United Kingdom |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Aromatic hydrocarbons
Leukaemia
Blood diseases
|
