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CISDOC database

Document ID (ISN)65743
CIS number 95-2141
ISSN - Serial title 1040-8444 - Critical Reviews in Toxicology
Year 1994
Convention or series no.
Author(s) Smith R.P., Wilcox D.E.
Title Toxicology of selected nitric oxide-donating xenobiotics, with particular reference to azide
Bibliographic information Oct. 1994, Vol.24, No.4, p.355-377. 129 ref.
Abstract Although nitric oxide (NO) is responsible for a variety of normal physiological functions, it has also been implicated in several pathophysiological processes. Recently, a variety of xenobiotics have been shown to owe their biological activity in vivo to their biotransformation to NO. As reviewed here, NO does not appear to contribute importantly to the toxicity of NO donors nitrite, hydroxylamine or nitroprusside. However, it is not clear if NO generated in vivo from sodium azide contributes in a major way to its toxicity. Some evidence suggests a tendency for azide to produce low-grade cumulative toxicity. Azide is widely used as a preservative in aqueous laboratory reagents and as a propellant in automobile air bags and aircraft escape chutes. To protect workers who handle these devices and others who may come into contact with the sodium azide propellant in these systems, the rudimentary knowledge of azide toxicity needs to be expanded.
Descriptors (primary) toxic effects; azides; nitric oxide; antibiotics; nitrogen oxides; drugs
Descriptors (secondary) literature survey; sodium azide; hydroxylamine; vasodilatation
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances