| Document ID (ISN) | 65737 |
| CIS number |
95-2139 |
| ISSN - Serial title |
0340-5761 - Archives of Toxicology |
| Year |
1994 |
| Convention or series no. |
|
| Author(s) |
Jung D., Konietzko J., Reill-Konietzko G., Muttray A., Zimmermann-Hölz H.J., Doss M., Beck H., Edler L., Kopp-Schneider A. |
| Title |
Porphyrin studies in TCDD-exposed workers |
| Bibliographic information |
1994, Vol.68, No.9, p.595-598. 18 ref. |
| Abstract |
2,3,7,8,-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to inhibit uroporphyrinogen decarboxylase activity resulting in chronic hepatic porphyria. From a cross-sectional study of 170 workers in the chemical industry 68 showed elevated coproporphyrin levels, interpreted as secondary coproporphyrinuria. Three persons suffered from chronic hepatic porphyria in subclinical stages. None of the workers showed an overt porphyria cutanea tarda. A low-grade zinc protoporphyrinaemia was observed in three persons. Forty-three of the 170 workers were evaluable for investigating the effect of TCDD on porphyrin levels. No significant correlation was found between TCDD concentration in adipose tissue and the level of uroporphyrin and coproporphyrin. The influence of a chloracne history is described. |
| Descriptors (primary) |
tetrachlorodibenzodioxin; dioxins; porphyrin metabolism; hepatic diseases; porphyria |
| Descriptors (secondary) |
chloracne; urinary coproporphyrin monitoring; cross-sectional study |
| Document type |
D - Periodical articles |
| Country / State or Province | Germany |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Heterocyclic compounds
Metabolic diseases
Liver diseases
Blood diseases
|
