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Document ID (ISN)65727
CIS number 95-2155
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 1995
Convention or series no.
Author(s) Gawkrodger D.J., Healy J., Howe A.M.
Title The prevention of nickel contact dermatitis: A review of the use of binding agents and barrier creams
Bibliographic information May 1995, Vol.32, No.5, p.257-265. Illus. 54 ref.
Abstract Chelating agents and other substances can be used to bind nickel or reduce its penetration through the skin and hence to reduce the symptoms of nickel sensitivity. Topical usage is mostly described but chelating agents are also used systemically. The most effective ligand for nickel has been proved to be 5-chloro-7-iodoquinolin-8-ol (clioquinol). Although normally regarded as safe, its usage in some situations may be limited by concerns about its toxicity. Other ligands with demonstrable effect include EDTA, diphenylglyoxime and dimethylglyoxime. Cation exchange resins can effectively bind nickel and work through the skin. Corticosteroids and cyclosporin work in nickel dermatitis by suppressing the immunological reaction rather than through an effect on nickel. Studies of the oral administration of ligands have given conflicting results. Further work is required to develop the existing agents and to look at the use of novel combinations.
Descriptors (primary) nickel; chelating agents; barrier creams; eczema; skin diseases
Descriptors (secondary) corticoids; cyclosporine; EDTA; propylene glycol; disulfiram; ion exchange; dimethylglyoxime
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases
Nickel and compounds
Inorganic substances
Skin protection