| Document ID (ISN) | 64872 |
| CIS number |
95-1407 |
| ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
| Year |
1992 |
| Convention or series no. |
|
| Author(s) |
Soskolne C.L., Jhangri G.S., Siemiatycki J., Lakhani R., Dewar R., Burch J.D., Howe G.R., Miller A.B. |
| Title |
Occupational exposure to sulfuric acid in southern Ontario, Canada, in association with laryngeal cancer |
| Bibliographic information |
Aug. 1992, Vol.18, No.4, p.225-232. 25 ref. |
| Abstract |
A case-referent study designed to test the association between exposure to asbestos and nickel and the development of laryngeal cancer was conducted in southern Ontario (Canada) in 1977-1979. For the primary study, the cases were individually matched with neighbourhood controls for sex and age. Personal interviews had secured smoking, alcohol and detailed work histories. To 183 of the male pairs were added retrospective assessments of sulfuric acid exposure for each job, blind of disease status; this constituted the data base for an augmented secondary analysis. Logistic regression revealed statistically significant odds ratios when tobacco and alcohol were controlled. Exposure-response gradients were strongly positive with odds ratios of 1.97 for short duration-low level exposure through 6.91 for long duration-higher level exposure employing progressively more specific definitions of exposure. Asbestos as a confounder and the interaction terms examined were nonsignificant. These findings are corroborative of those of other studies. |
| Descriptors (primary) |
Canada; Ontario; carcinogenic effects; occupation disease relation; sulfuric acid; laryngeal cancer |
| Descriptors (secondary) |
nickel; asbestos; alcoholism; mathematical analysis; exposure evaluation; case-control study; dose-response relationship; smoking |
| Document type |
D - Periodical articles |
| Country / State or Province | Canada |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Alcohol and drug abuse
Diseases of the respiratory system (except for pneumoconiosis & similar)
Inorganic sulfur compounds
|
