Document ID (ISN) | 64864 |
CIS number |
95-1314 |
ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
Year |
1994 |
Convention or series no. |
|
Author(s) |
Boujemaa W., Lauwerys R., Bernard A. |
Title |
Early indicators of renal dysfunction in silicotic workers |
Bibliographic information |
June 1994, Vol.20, No.3, p.180-183. 17 ref. |
Abstract |
The aim of the study was to determine whether silicosis is associated with renal alterations detectable in urinary or blood-borne indicators of nephrotoxicity. Subjects comprised 116 male workers who had been exposed to silica for a least two years and had been diagnosed as having silicosis and 61 age-matched controls. The considered outcome measures were the concentrations of beta2-microglobulin and creatinine in serum and the urinary excretion of albumin, retinol-binding protein and beta-N-acetyl-D-glucosaminidase. Compared with the controls, the silicotic subjects excreted, on average, slightly higher amounts of albumin, retinol-binding protein and beta-N-acetyl-D-glucosaminidase. The concentration of beta2-microglobulin in the serum of silicotic subjects showed a tendency to rise that became significant in the subgroup with pseudotumoral opacities. These results confirm that silicosis is associated with some infraclinical renal alterations. However, in the absence of a relationship with length of exposure or severity of silicosis, the implication of silica in their causation needs to be examined further. |
Descriptors (primary) |
renal dysfunction; silica; exposure tests; nephrotoxic effects; medical supervision; silicosis |
Descriptors (secondary) |
proteinuria; questionnaire survey; urine monitoring; statistical evaluation; blood monitoring; case-control study |
Document type |
D - Periodical articles |
Country / State or Province | Belgium |
Subject(s) |
Dust, aerosols and related diseases
|
Broad subject area(s) |
Occupational medicine, epidemiology
|
Browse category(ies) |
Diseases of the kidney and the urinary system Biological monitoring Pneumoconioses
|