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Document ID (ISN)64555
CIS number 95-1025
ISSN - Serial title 1250-3274 - Archives des maladies professionnelles et de médecine du travail
Year 1994
Convention or series no.
Author(s) Zissu D., Gervais P.
Title Glutaraldehyde - Importance in hospitals and precautions for use
Original title Le glutaraldéhyde - Intérêt en milieu hospitalier et précautions d'emploi [in French]
Bibliographic information 1994, Vol.55, No.6, p.463-466. 12 ref.
Abstract The properties of glutaraldehyde, widely used in the cold sterilization of medical and surgical equipment, are reviewed. Over the last 10 years, an increasing number of pathological symptoms have been cited among hospital workers exposed to glutaraldehyde. Experiments in rodents have shown an irritant effect of this aldehyde on the upper respiratory tract, at a concentration ten times lower than the value of the RD50 (2.6ppm in the mouse). Glutaraldehyde also induces dermatoses among exposed medical personnel; the Draize protocol indicated an irritant effect on the skin and the eyes in albino rabbits, while when using maximization tests of the Kligman and Magnusson type, a crossed cutaneous sensitization between glutaraldehyde, formaldehyde and glyoxal was observed in the guinea-pig. In-vitro toxicological studies showed the genotoxic potential of glutaraldehyde. Glutaraldehyde must be handled with care and medical advice should be sought for any serious incident or accident.
Descriptors (primary) glutaraldehyde; health engineering; hospitals; health services; limitation of exposure
Descriptors (secondary) formaldehyde; disinfection of equipment; glyoxal; toxicology; genetic effects; safety and health engineering; toxicity evaluation; animal experiments; skin diseases
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Commerce, services, offices
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Health care services