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CISDOC database

Document ID (ISN)64173
CIS number 95-674
ISBN(s) 3-7776-0577-8
Year 1994
Convention or series no. BUA Report 84
Author(s)
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Title N,N-Dimethylformamide
Bibliographic information S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1994. xiii, 84p. 188 ref. Price: DEM 48.00.
Abstract Dimethylformamide (DMF) is readily absorbed orally, dermally and by inhalation. The main effects are hepatotoxic effects following both acute and chronic exposure. Other effects include irritation of the skin and mucous membranes, skin sensitization, eczema, neurotoxic effects, cardiovascular and gastrointestinal complaints and damage to the kidneys and other organs. DMF also leads to synergistic effects with alcohol or to alcohol intolerance reactions. Embryotoxic and teratogenic effects have been observed in experimental animals and there are reports of increased chromosome aberrations in humans. Reports of a possible relationship between cancer and DMF exposure have not been confirmed.
Descriptors (primary) Germany; dimethylformamide; ecotoxicology; organic solvents; toxicology
Descriptors (secondary) toxic effects; criteria document; irritants; hepatotoxic effects; skin absorption; renal damage; cardiovascular disorders; eczema; sensitizers; gastrointestinal diseases; permissible levels; animal experiments; chromosome changes; synergism; carcinogenic effects; literature survey
Document type E - Books, reports, proceedings
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Amides
Pollution control