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Document ID (ISN)63993
CIS number 95-573
ISSN - Serial title 1250-3274 - Archives des maladies professionnelles et de médecine du travail
Year 1994
Convention or series no.
Author(s) Crépy M.N., Conso F.
Title Occupational scleroderma-like disorders
Original title Sclérodermie et facteurs professionnels (ou environnementaux) [in French]
Bibliographic information 1994, Vol.55, No.2, p.111-118. 49 ref.
Abstract Several environmental substances have been reported as contributing factors in progressive systemic sclerosis and in so-called scleroderma-like diseases. Contaminated rapeseed oil in Spain and administration of drug containing L-tryptophan were found responsible for the outbreak of two scleroderma-like epidemics. Paraffin and silicone implants, bleomycin and pentazocine were among the iatrogenic factors. Two occupational factors are already well-known: silica and vinyl chloride. Others are only suspected: solvents, and epoxy resins. Identification of these substances presents two main interests: environmental exposure can be limited and the pathogenesis of scleroderma being unknown, inducing factors may be used in experimental models for research.
Descriptors (primary) scleroderma; environment; skin diseases; occupation disease relation
Descriptors (secondary) epoxy resins; vinyl chloride; organic solvents; silica; paraffin wax; tryptophan
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Skin diseases