|Document ID (ISN)||63993|
|ISSN - Serial title
||1250-3274 - Archives des maladies professionnelles et de médecine du travail
|Convention or series no.
||Crépy M.N., Conso F.
||Occupational scleroderma-like disorders
||Sclérodermie et facteurs professionnels (ou environnementaux) [in French]|
||1994, Vol.55, No.2, p.111-118. 49 ref.
||Several environmental substances have been reported as contributing factors in progressive systemic sclerosis and in so-called scleroderma-like diseases. Contaminated rapeseed oil in Spain and administration of drug containing L-tryptophan were found responsible for the outbreak of two scleroderma-like epidemics. Paraffin and silicone implants, bleomycin and pentazocine were among the iatrogenic factors. Two occupational factors are already well-known: silica and vinyl chloride. Others are only suspected: solvents, and epoxy resins. Identification of these substances presents two main interests: environmental exposure can be limited and the pathogenesis of scleroderma being unknown, inducing factors may be used in experimental models for research.
||scleroderma; environment; skin diseases; occupation disease relation
||epoxy resins; vinyl chloride; organic solvents; silica; paraffin wax; tryptophan
||D - Periodical articles
|Country / State or Province||France|
|Broad subject area(s)
||Occupational medicine, epidemiology