| Document ID (ISN) | 63574 |
| CIS number |
95-210 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1994 |
| Convention or series no. |
|
| Author(s) |
Huang M.Y., Jin C., Liu Y.T., Li B.H., Qu Q.S., Uchida Y., Inoue O., Nakatsuka H., Watanabe T., Ikeda M. |
| Title |
Exposure of workers to a mixture of toluene and xylenes - I. Metabolism |
| Bibliographic information |
Jan. 1994, Vol.51, No.1, p.42-46. Illus. 34 ref. |
| Abstract |
The urinary excretion of hippuric acid and methylhippuric acid was studied in 233 subjects in China (122 men and 111 women) exposed to toluene and xylenes in combination and in 281 non-exposed controls (141 men and 140 women) recruited from the same factories or factories of the same region. Smoking and drinking habits of the subjects were obtained by medical interviews. A urine sample was collected from each worker at the end of a shift and was analyzed for hippuric and methylhippuric acids by high performance liquid chromatography. Air samples for the estimation of toluene and xylenes were collected with diffusive personal samplers. There was a linear correlation between the time-weighted average exposure either to toluene or xylene isomers and the concentrations of hippuric acid or methylhippuric acid isomers in urine. The metabolism of toluene and xylenes was significantly reduced among smokers or drinkers compared with non-smokers and non-drinkers. |
| Descriptors (primary) |
chemical industry; toluene; metabolic studies; xylene; urinary metabolites; mixtures |
| Descriptors (secondary) |
China; metabolic process; hippuric acid; alcoholism; high-pressure liquid chromatography; urinary excretion; case-control study; urine monitoring; smoking |
| Document type |
D - Periodical articles |
| Country / State or Province | China; Japan |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Chemical industry
Alcohol and drug abuse
Aromatic hydrocarbons
|
