|Document ID (ISN)||63228|
|ISSN - Serial title
||0002-9262 - American Journal of Epidemiology
|Convention or series no.
||Hirota Y., Hirohata T., Fukuda K., Mori M., Yanagawa H., Ohno Y., Sugioka Y.I.
||Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head
||1 Mar. 1993, Vol.137, No.5, p.530-538. 35 ref.
||The association of alcohol intake, cigarette smoking, occupation, and other factors with the development of idiopathic osteonecrosis of the femoral head was studied in Japan during the period 1988-1990, comparing 118 cases with no history of systemic corticosteroid use with 236 controls. The risks of developing femoral head necrosis associated with potential risk factors were estimated by adjusted relative odds. The elevated relative odds were observed for occasional and regular drinkers, with a significant dose-response relation (p<0.001). An increased risk was found for current smokers, but a linear increasing trend in the cumulative effect of smoking was not evident at 20 pack-years or over. A weak but significant dose-response relation was observed for daily occupational energy consumption (p<0.05). The present study confirmed the strong association of alcohol intake and positive association of cigarette smoking and suggested the role of heavy physical work.
||bone diseases; alcoholism; osteonecrosis; occupation disease relation; smoking
||Japan; heavy work; dose-response relationship; risk factors; epidemiologic study
||D - Periodical articles
|Country / State or Province||Japan|
|Broad subject area(s)
||Occupational medicine, epidemiology
||Diseases of the musculoskeletal system
Alcohol and drug abuse