ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)63222
CIS number 94-1983
ISSN - Serial title 0002-9262 - American Journal of Epidemiology
Year 1993
Convention or series no.
Author(s) Gowers D.S., DeFonso L.R., Schaffer P., Karli A., Monroe C.B., Bernabeu L., Renshaw F.M.
Title Incidence of respiratory cancer among workers exposed to chloromethyl-ethers
Bibliographic information 1 Jan. 1993, Vol.137, No.1, p.31-42. Illus. 32 ref.
Abstract The purpose of this cohort study was to determine whether workers at a factory in France whose jobs had involved potential exposure to chloromethyl-methyl-ether since 1958 had a higher incidence of lung cancer than co-workers, or others without potential exposure. Lung cancer occurred at a higher rate among potentially exposed workers than among non-exposed workers (rate ratio (RR)=5.0, 95% confidence interval (CI) 2.0-12.3), or among an external reference population (RR=7.6, 95% CI 4.3-13.5). The average age at diagnosis for exposed cases was 10.5 years lower than for non-exposed cases. There was a positive dose-response relationship. The mean time from first exposure to diagnosis was 13 years (95% CI 8-18). Cumulative dose and induction time were not associated. The rate for the exposed workers peaked between 7 and 13 years after the start-up of the chloromethylation process, and was still above background in 1986, the end of the study period.
Descriptors (primary) chloromethyl methyl ether; lung cancer; long-term exposure; cancer; bis(chloromethyl) ether
Descriptors (secondary) France; dose-response relationship; cohort study
Document type D - Periodical articles
Country / State or ProvinceFrance; USA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Ethers
Diseases of the respiratory system (except for pneumoconiosis & similar)