|Document ID (ISN)||63222|
|ISSN - Serial title
||0002-9262 - American Journal of Epidemiology
|Convention or series no.
||Gowers D.S., DeFonso L.R., Schaffer P., Karli A., Monroe C.B., Bernabeu L., Renshaw F.M.
||Incidence of respiratory cancer among workers exposed to chloromethyl-ethers
||1 Jan. 1993, Vol.137, No.1, p.31-42. Illus. 32 ref.
||The purpose of this cohort study was to determine whether workers at a factory in France whose jobs had involved potential exposure to chloromethyl-methyl-ether since 1958 had a higher incidence of lung cancer than co-workers, or others without potential exposure. Lung cancer occurred at a higher rate among potentially exposed workers than among non-exposed workers (rate ratio (RR)=5.0, 95% confidence interval (CI) 2.0-12.3), or among an external reference population (RR=7.6, 95% CI 4.3-13.5). The average age at diagnosis for exposed cases was 10.5 years lower than for non-exposed cases. There was a positive dose-response relationship. The mean time from first exposure to diagnosis was 13 years (95% CI 8-18). Cumulative dose and induction time were not associated. The rate for the exposed workers peaked between 7 and 13 years after the start-up of the chloromethylation process, and was still above background in 1986, the end of the study period.
||chloromethyl methyl ether; lung cancer; long-term exposure; cancer; bis(chloromethyl) ether
||France; dose-response relationship; cohort study
||D - Periodical articles
|Country / State or Province||France; USA|
|Broad subject area(s)
Diseases of the respiratory system (except for pneumoconiosis & similar)