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CISDOC database

Document ID (ISN)63037
CIS number 94-1763
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1993
Convention or series no.
Author(s) Gottlieb S.J., Garibaldi E., Hutcheson P.S., Slavin R.G.
Title Occupational asthma to the slime mold Dictyostelium discoideum
Bibliographic information Dec. 1993, Vol.35, No.12, p.1231-1235. Illus. 25 ref.
Abstract Dictyostelium discoideum is a slime mould that exists in a unicellular amoeboid form under certain nutritional conditions. In this form it produces unique lysosomal enzymes that are valuable in studying cell-to-cell signalling systems. A research microbiologist developed rhinoconjunctivitis and asthma after release of the organism from a pressurized canister. Immediate skin-test reactivity to whole and lysed organisms was demonstrated. Enzyme-linked immunosorbent assay results revealed IgE antibody against whole organisms, lysed organisms, and lysosomal enzymes with the strongest response being directed toward lysosomal enzymes. Pulmonary function testing showed a decline in forced expiratory volume in one second and forced expiratory flow after modified laboratory exposure to D. discoideum. This case represents the first report of occupational rhinoconjunctivitis and asthma from slime mould.
Descriptors (primary) laboratory work; biological hazards; allergic asthma; fungi
Descriptors (secondary) rhinitis; case study; microorganisms; respiratory function tests; conjunctivitis; one-second forced expiratory volume; maximal expiratory flow
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Biological hazards
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Biological hazards