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Document ID (ISN)62814
CIS number 94-1225
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1993
Convention or series no.
Author(s) Franco G., Fonte R., Ghittori S.
Title Drinking habits and occupational exposure to inhalation anesthetics at low doses
Bibliographic information Nov.-Dec. 1993, Vol.84, No.6, p.463-472. Illus. 54 ref.
Abstract The aim of this study was to evaluate certain indicators of hepatic (serum aminotransferase activities) and haematological (erythrocyte mean corpuscular volume) changes among health care personnel exposed to inhalation anaesthetics (nitrous oxide and isoflurane). Workers (172) in a hospital were divided into four groups according to exposure and drinking habits: (1) non-drinkers and unexposed subjects; (2) drinkers and unexposed subjects; (3) non-drinkers and exposed subjects; (4) drinkers and exposed subjects. Aminotransferase activity or mean erythrocyte size were not affected by anaesthetics exposure. Increased aspartateaminotransferase (AST) values among unexposed drinkers were related to alcohol intake. This observation was confirmed by the relationship between AST behaviour and quantitative alcohol intake. Thus, when studying any effect involving functions related to the biotransformation of xenobiotics, in which the liver plays a primary role, the importance of establishing the exact daily amount of ethanol intake is stressed.
Descriptors (primary) metabolic process; ethanol; inhalation anaesthetics; synergism; isoflurane; haematological changes; health care personnel; nitrous oxide
Descriptors (secondary) enzyme activity; blood count
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Blood diseases
Inorganic substances
Ethers
Alcohols
Health care services