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Document ID (ISN)62692
CIS number 94-1302
ISSN - Serial title 0867-8383 - Polish Journal of Occupational Medicine and Environmental Health
Year 1993
Convention or series no.
Author(s) Górecka D., Górski T.
Title The influence of cigarette smoking on sister chromatid exchange frequencies in peripheral lymphocytes among nurses handling cytostatic drugs
Bibliographic information 1993, Vol.6, No.2, p.143-148. Illus. 11 ref.
Abstract Genotoxic compounds and various cancer chemotherapeutic agents can interact with tobacco smoke synergistically, especially among cigarette smoking nurses who handle cytostatic drugs. The aim of the study was to examine the hypothesis that tobacco smoking has a greater influence on sister chromatid exchange (SCE) frequencies among nurses than the influence of cytostatics in working conditions. The frequencies of SCE in lymphocytes investigated among hospital staff who handle anti-cancer drugs were higher than in a control group which did not handle them (smokers and non-smokers). The increase of SCE frequencies was observed more often among cigarette smoking nurses and less among non-smoking nurses who handle cytostatics 3 times a week.
Descriptors (primary) cytostatic drugs; smoking; analysis of chromosome aberrations; nursing personnel; chromosome changes; hospitals
Descriptors (secondary) materials handling; case-control study; lymphocytes; dangerous substances
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Health care services
Genetic factors in reaction to exposures