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CISDOC database

Document ID (ISN)62598
CIS number 94-1288
ISSN - Serial title 0091-6765 - Environmental Health Perspectives
Year 1993
Convention or series no.
Author(s) Melnick R.L., Shackelford C.C., Huff J.
Title Carcinogenicity of 1,3-butadiene
Bibliographic information Apr. 1993, Vol.100, p.227-236. Illus. 50 ref.
Abstract 1,3-Butadiene, a high-production-volume chemical used widely in the manufacture of synthetic rubber, is a multiple organ carcinogen in rats and mice. Human exposures by workers employed at facilities that produce this chemical and at facilities that produce styrene-butadiene rubber have been measured at levels higher than those that cause cancer in animals. Furthermore, epidemiological studies have consistently revealed associations between occupational exposure to 1,3-butadiene and excess mortality due to lymphatic and haematopoietic cancers. In response to the carcinogenicity findings for 1,3-butadiene in animals and in humans, the US Occupational Safety and Health Administration has proposed lowering the occupational exposure standard for this chemical from 1,000ppm to 2ppm. Future work is needed to understand the mechanisms of tumour induction by 1,3-butadiene; however, the pursuit of this research should not delay the reduction of human exposure to this chemical.
Descriptors (primary) carcinogens; carcinogenic effects; cancer; butadiene
Descriptors (secondary) literature survey; threshold limit values; epidemiological aspects; rodents; lymphoma; synthetic rubber industry; inhalation; permissible levels; animal experiments; dose-response relationship; mortality
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aliphatic and alicyclic hydrocarbons