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Document ID (ISN)62555
CIS number 94-1309
ISSN - Serial title 0022-443X - Journal of Science of Labour - Rōdō Kagaku
Year 1993
Convention or series no.
Author(s) Hanaoka T., Ishizu S., Yamano Y.
Title Effects of cigarette smoking on lymphocyte subsets in office workers
Bibliographic information Oct. 1993, Vol.69, No.10, p.15-20. Illus. 19 ref.
Abstract Some immunotoxicological studies have applied the analysis of lymphocyte subsets to the detection of biological effects of chemical exposures. The purpose of this research was to examine the effects of cigarette smoking and alcohol drinking on lymphocyte subsets. Some lymphocyte subsets in healthy office workers (n=36) with no industrial exposure to chemicals were determined. A significant increase of the total peripheral white blood cell counts, the total lymphocyte counts, the percentages of CD4+CD45RA-cells and CD25 positive cells was found in smokers (n=16) compared to non-smokers (n=20). A positive correlation was also observed between the percentage of CD4+CD45RA-cells and the Brinkman index (p<0.05) and between the percentage of CD20 positive cells and the Brinkman index (p<0.1). Furthermore, a negative correlation was seen between the percentage of CD8+CD11b-cells and Brinkman index (p<0.05). On the other hand, no effects of alcohol drinking and age were observed on the percentages of lymphocyte subsets. Thus, it is necessary to take into account smoking habits in industrial toxicological studies using the analysis of lymphocyte subsets.
Descriptors (primary) lymphocytes; haematological effects; smoking
Descriptors (secondary) office work; Japan
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Smoking
Blood diseases