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CISDOC database

Document ID (ISN)62486
CIS number 94-971
ISSN - Serial title 0342-0809 - Kompass
Year 1993
Convention or series no.
Author(s) Potthast J., Marek W., Marczynski B., Baur X.
Title Isocyanates on the workplace - Diseases of the respiratory tract and the lung
Original title Isocyanate am Arbeitsplatz - Erkrankungen der Atemwege und der Lunge [in German]
Bibliographic information July 1993, Vol.103, No.7, p.338-345. Illus. 33 ref.
Abstract The results of experimental studies of the effects of isocyanates such as diphenylmethane diisocyanate (MDI), tolylene diisocyanate (TDI) and hexamethylene diisocyanate (HDI) over a two-year period are summarized. In vivo short-term exposure to 10ppb TDI led to bronchial hypersensitivity. In vivo and in vitro exposure to the isocyanates produced breaks in DNA. A reduction of the present maximum workplace concentration for TDI is recommended.
Descriptors (primary) diphenylmethane diisocyanate; hexamethylene diisocyanate; tolylene diisocyanate; construction industry; motor vehicle industry; allergic reactivity; furniture industry; respiratory impairment; anthracite mining; allergic respiratory disorders; hypersensitivity
Descriptors (secondary) allergens; obstructive ventilatory impairment; in vitro experiments; experimental pathology; isocyanates
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Lumber and the woodworking industry
Mining and quarrying
Motor vehicle manufacturing industry
Construction industry and civil engineering
Cyano compounds
Woodworking industry