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Document ID (ISN)62313
CIS number 94-880
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1993
Convention or series no.
Author(s) Frumkin H., Gerr F.
Title Dimercaptosuccinic acid in the treatment of depression following lead exposure
Bibliographic information Dec. 1993, Vol.24, No.6, p.701-706. 17 ref.
Abstract Long-term exposure to lead is known to cause a variety of neurotoxic manifestations, including symptoms of depression. Dimercaptosuccinic acid (DMSA), a recently approved oral chelating agent, can diminish the body burden of lead, but few cases of documented clinical improvement following treatment have been reported. We report a case of moderate to severe depression in a long-term lead worker that appeared to respond dramatically to DMSA. This response suggests a possible therapeutic role for DMSA in the treatment of depression in lead-exposed patients.
Descriptors (primary) lead; dimercaptosuccinic acid; chelation therapy; chronic poisoning; toxic substances
Descriptors (secondary) case study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Lead and compounds
Inorganic substances