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CISDOC database

Document ID (ISN)62273
CIS number 94-877
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1993
Convention or series no.
Author(s) Fleming L.E., Timmeny W.
Title Aplastic anemia and pesticides: an etiologic association?
Bibliographic information Nov. 1993, Vol.35, No.11, p.1106-1116. 38 ref.
Abstract The majority of cases of aplastic anaemia, a rare previously lethal disease, are of unknown aetiology. Nevertheless, for the past three decades, case reports and case series of aplastic anaemia have suggested an aetiological association between aplastic anaemia and pesticide exposure. A review of the medical literature, including basic science literature, provides support for this possible association. Two hundred and eighty cases of aplastic anaemia associated with pesticide exposure were reported in the literature. The majority of these cases were young (mean age 34yrs; median, 28), with a short latency (mean, 5 months) and with a history of occupational exposure to pesticides. The pesticide exposures reported were to organochlorines and organophosphates, both commonly used types of pesticides throughout the world. Therapeutic and methodological issues as well as future directions for research into this aetiological association are discussed.
Descriptors (primary) aplastic anaemia; pesticides; aetiology
Descriptors (secondary) literature survey
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Blood diseases
Agricultural chemicals