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CISDOC database

Document ID (ISN)62271
CIS number 94-953
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1993
Convention or series no.
Author(s) Heseltine E., Peltonen K., Sorsa M., Vainio H.
Title Assessment of the health hazards of 1,3-butadiene and styrene
Bibliographic information Nov. 1993, Vol.35, No.11, p.1089-1095. 6 ref.
Abstract Report on a meeting held in Espoo, Finland, 18-21 April 1993, on the health hazards of 1,3-butadiene and styrene. The main topics were occurrence and exposure, dose measurement, protein and DNA adducts as markers of exposure, reproductive effects and neurotoxicity, genetic toxicity, cancer. The two substances have carcinogenic effects in laboratory studies but wide differences between species make extrapolation to humans difficult. Epidemiological evidence associating butadiene exposure with cancer is strong, but the data on styrene are still equivocal. Research in several areas is needed.
Descriptors (primary) carcinogens; styrene; chemical hazards; hazard evaluation; butadiene
Descriptors (secondary) neurotoxic effects; antifertility effects; round-up; conference; cancer
Document type D - Periodical articles
Country / State or ProvinceFinland; France
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation
Genetic factors in reaction to exposures
Aromatic hydrocarbons
Aliphatic and alicyclic hydrocarbons