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CISDOC database

Document ID (ISN)62214
CIS number 94-872
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1991
Convention or series no.
Author(s) Amandus H., Costello J.
Title Silicosis and lung cancer in U.S. metal miners
Bibliographic information Mar.-Apr. 1991, Vol.46, No.2, p.82-89. 31 ref.
Abstract The association between silicosis and lung cancer mortality was estimated in 9,912 (369 silicotics and 9,543 nonsilicotics) white male metal miners. These miners were examined by the U.S. Public Health Service during 1959-1961 and were followed through 1975. The ores that were mined consisted of copper, lead-zinc, iron, mercury, lead silver, gold and gold-silver, tungsten, and molybdenum. The standardized mortality ratio (SMR, U.S. white male rates) for lung cancer was 1.73 (95% CI: 0.94-2.90) in silicotics and 1.18 (95% CI: 0.98-1.42) in nonsilicotics. When lung cancer mortality between silicotics and nonsilicotics was compared, the age-adjusted rate ratio (95% CI) was 1.56 (0.91-2.68), and the age- and smoking adjusted rate ratio was 1.96 (0.98-3.67). Corresponding figures for miners who were employed in mines with low levels of radon exposure were 1.90 (0.98-3.67) and 2.59 (1.44-4.68), respectively. These findings indicate that lung cancer mortality risk was increased in silicotics, and this probably did not result from chance or bias. However, confounding from radon exposure could not be ruled out.
Descriptors (primary) USA; radon; mortality; metal mining; lung cancer; silicosis; occupation disease relation
Descriptors (secondary) neoplasms; cohort study
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Pneumoconioses
Mining and quarrying
Inorganic substances
Radon