Document ID (ISN) | 62045 |
CIS number |
94-631 |
ISSN - Serial title |
0096-1736 - Journal of Occupational Medicine |
Year |
1993 |
Convention or series no. |
|
Author(s) |
Scolnick B., Hamel D., Woolf A.D. |
Title |
Successful treatment of life-threatening propionitrile exposure with sodium nitrite/sodium thiosulfate followed by hyperbaric oxygen |
Bibliographic information |
June 1993, Vol.35, No.6, p.577-580. 28 ref. |
Abstract |
Case report on two workers at a chemical plant who were overcome by propionitrile fumes. One victim was comatose, acidotic, and hypertensive (blood cyanide level 5.0µg/mL). The second victim complained of nausea, dizziness, and headache but never lost consciousness (blood cyanide level 3.5µg/mL). The ambient concentration of propionitrile in air samples after exposure was 77.5mg/m3. Both workers received sodium nitrite/sodium thiosulfate (the first one also received hyperbaric oxygen for 4h). In occupational situations in which workers exhibit sudden symptoms of acute poisoning and where substituted nitriles are known to be on site, acute cyanide poisoning should be suspected. Hyperbaric oxygen may be a valuable adjunctive therapy to consider in addition to normal first-aid measures. |
Descriptors (primary) |
toxic effects; chemical industry; toxic substances; propionitrile; acute poisoning |
Descriptors (secondary) |
case study; cyanides; medical treatment; emergency treatment; coma |
Document type |
D - Periodical articles |
Country / State or Province | USA |
Subject(s) |
Chemicals, plastics and rubber
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Cyano compounds Chemical industry
|