| Document ID (ISN) | 61883 |
| CIS number |
94-641 |
| ISBN(s) |
90-399-0518-5 |
| Year |
1993 |
| Convention or series no. |
Arbeidsinspectie RA 3/93
|
| Author(s) |
Department of Social Affairs and Employment, Directorate-General of Labour (Ministerie van Sociale Zaken en Werkgelegenheid, Directoraat-Generaal van de Arbeid) |
| Title |
Health-based recommended occupational exposure limit for pyridine |
| Bibliographic information |
SDU Uitgeverij Plantijnstraat, Afdeling Verkoop Publikaties Arbeidsinspectie, Postbus 20014, 2500 EA Den Haag, Netherlands, 1993. 8+20p. Illus. Bibl.ref. |
| Abstract |
This publication (prepared in cooperation between the Dutch Expert Committee for Occupational Standards (DEC) and the Swedish Criteria Group (SCG), whose criteria document on pyridine in the series Arbete och hälsa 1991:49 by M. Warholm has already been abstracted as CIS 93-610) presents an evaluation of the health hazards of exposure to pyridine. This substance is mainly used as a solvent and is also an intermediate in the production of e.g. pharmaceutical and agricultural chemicals. Attention is given to: identity, physical and chemical properties, analytical methods; toxicokinetic data; general toxicological effects in animal and humans (short-term exposure and long-term exposure); effects on organs; biochemical effects; reproductive effects and effects on pregnancy; mutagenicity; carcinogenicity; evaluation of human health risks. The critical health effect of pyridine seems to be its effect on the central nervous system and the liver. Based on the data available, the Dutch Expert Committee recommends a health-based occupational exposure limit for pyridine of 1mg/m3 (0.3ppm), 8h-TWA, with a skin notation. Detailed summary in Dutch. |
| Descriptors (primary) |
threshold limit values; Sweden; Netherlands; biological effects; determination of exposure limits; health hazards; pyridine |
| Descriptors (secondary) |
toxic effects; neurotoxic effects; literature survey; irritants; criteria document; hepatic damage; renal damage; toxicity evaluation; report |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | Netherlands; Sweden |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Occupational exposure limits
Heterocyclic compounds
|
