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CISDOC database

Document ID (ISN)61612
CIS number 94-293
ISSN - Serial title 0748-2337 - Toxicology and Industrial Health
Year 1992
Convention or series no.
Author(s) Dourson M.L., Knauf L.A., Swartout J.C.
Title On reference dose (RfD) and its underlying toxicity data base
Bibliographic information May-June 1992, Vol.8, No.3, p.171-189. Illus. 18 ref.
Abstract Toxicity data on pesticides were summarized and compared amongst different animal species and types of bioassays. These comparisons showed the expected variability. After quantitative and statistical analysis, it was concluded that, on the average, a two-year dog bioassay detected toxic responses at similar doses as a two-year rat study, and that both of these bioassays detected toxic responses at lower doses than either a rat two-generation bioassay, a rat developmental toxicity study, or a two-year mouse bioassay. Although these chronic dog and rat bioassays were found to detect toxic responses at lower doses than the other studies listed, this analysis does not reflect the seriousness of the effects that were compared. Within the confines of this analysis, then, it appears that a two-year dog and rat study, reproductive and developmental bioassays are a sufficient data base on which to estimate high confidence Reference Doses (RfDs), and furthermore, that an additional uncertainty factor is needed to estimate RfDs to account for this variability when fewer than this number of bioassays are available.
Descriptors (primary) toxic effects; pesticides; toxic substances; toxicity evaluation; animal experiments; safety and health documentation; dose-response relationship; experimental pathology
Descriptors (secondary) literature survey; dogs; comparative study; extrapolation animal man; rodents
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Safety and health information
Agricultural chemicals