|Document ID (ISN)||61612|
|ISSN - Serial title
||0748-2337 - Toxicology and Industrial Health
|Convention or series no.
||Dourson M.L., Knauf L.A., Swartout J.C.
||On reference dose (RfD) and its underlying toxicity data base
||May-June 1992, Vol.8, No.3, p.171-189. Illus. 18 ref.
||Toxicity data on pesticides were summarized and compared amongst different animal species and types of bioassays. These comparisons showed the expected variability. After quantitative and statistical analysis, it was concluded that, on the average, a two-year dog bioassay detected toxic responses at similar doses as a two-year rat study, and that both of these bioassays detected toxic responses at lower doses than either a rat two-generation bioassay, a rat developmental toxicity study, or a two-year mouse bioassay. Although these chronic dog and rat bioassays were found to detect toxic responses at lower doses than the other studies listed, this analysis does not reflect the seriousness of the effects that were compared. Within the confines of this analysis, then, it appears that a two-year dog and rat study, reproductive and developmental bioassays are a sufficient data base on which to estimate high confidence Reference Doses (RfDs), and furthermore, that an additional uncertainty factor is needed to estimate RfDs to account for this variability when fewer than this number of bioassays are available.
||toxic effects; pesticides; toxic substances; safety and health documentation; toxicity evaluation; animal experiments; dose-response relationship; experimental pathology
||literature survey; dogs; comparative study; extrapolation animal man; rodents
||D - Periodical articles
|Country / State or Province||USA|
||Toxic and dangerous substances
|Broad subject area(s)
||Safety and health information