| Document ID (ISN) | 61579 |
| CIS number |
94-285 |
| ISSN - Serial title |
1040-8444 - Critical Reviews in Toxicology |
| Year |
1992 |
| Convention or series no. |
|
| Author(s) |
Waalkes M.P., Coogan T.P., Barter R.A. |
| Title |
Toxicological principles of metal carcinogenesis with special emphasis on cadmium |
| Bibliographic information |
1992, Vol.22, No.3-4, p.175-201. Illus. 171 ref. |
| Abstract |
Metals are an important and emerging class of carcinogens. Considering that the list of known human carcinogens of any type is very small, it becomes clear that metals make up a substantial proportion of the list. Despite this, relatively little attention has been given to the topic of metal carcinogenesis. Although no clear mechanisms of action have emerged in the area of metal carcinogenesis, it has become apparent that they are anything but simple. Metal carcinogens possess several unique characteristics including a remarkable target site specificity. Detection of the mechanism(s) of metal carcinogenesis has proven elusive, however, partly because of a wide diversity of metallic carcinogenic agents and the intricate nature of metal interactions in biological systems. This review explores this broad topic, with special emphasis on toxicological principles including dose-response relationships and potential mechanisms. |
| Descriptors (primary) |
carcinogens; metals; cadmium; dose-response relationship; carcinogenic effects; cancer |
| Descriptors (secondary) |
literature survey; genetic effects; animal experiments; epidemiologic study |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Genetic factors in reaction to exposures
Cadmium and compounds
|
