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CISDOC database

Document ID (ISN)61575
CIS number 94-199
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1992
Convention or series no.
Author(s) Brinkworth M.H., Yardley-Jones A., Edwards A.J., Hughes J.A., Anderson D.
Title A comparison of smokers and nonsmokers with respect to oncogene products and cytogenetic parameters
Bibliographic information Dec. 1992, Vol.34, No.12, p.1181-1188. Illus. 17 ref.
Abstract Human monitoring studies can be valuable tools for assessing the adverse effects of chemicals. Cytogenetic parameters have been frequently employed but are rarely related directly to possible adverse health effects. Recently, the measurement of oncoprotein levels in plasma has been proposed as a possible and more appropriate indicator of exposure and carcinogenic risk but, unlike chromosome damage, little is known about the effects of possible confounding factors. This study compared the effect of smoking on chromosome aberrations, sister chromatid exchange, and plasma rasoncoprotein levels, in 40 humans not otherwise known to be exposed to any specific chemical hazard. No effect was found on any of these end points, with the exception of a moderate, statistically non-significant elevation of sister chromatid exchange levels. It is concluded that smoking is unlikely to be a confounding factor in human monitoring studies using oncoprotein levels as an end point.
Descriptors (primary) smoking; cancer; cytology; exposure tests; cytogenetic studies; genetic effects
Descriptors (secondary) blood plasma; serum protein changes; analysis of chromosome aberrations; determination in blood; chromosome changes
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Biological monitoring
Smoking