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CISDOC database

Document ID (ISN)61215
CIS number 93-1942
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1993
Convention or series no.
Author(s) Bond G.G., Rossbacher R.
Title A review of potential human carcinogenicity of the chlorophenoxy herbicides MCPA, MCPP and 2,4-DP
Bibliographic information Apr. 1993, Vol.50, No.4, p.340-348. 53 ref.
Abstract For the purpose of assessing the human carcinogenic potential of the chlorophenoxy herbicides MCPA, MCPP, and 2,4-DP, the relevant epidemiological and toxicological evidence is reviewed. These compounds have not produced tumours in animal studies conducted under current test guidelines, giving no reason to predict that they would be carcinogenic in humans. Epidemiological studies have been conducted on three continents; greater emphasis is placed on the studies reported from western Europe, however, as this has been the area of more use. Although several of these studies provide suggestive evidence of associations between exposure to chlorophenoxy compounds and increased risks for some uncommon cancers, it is inconsistent and far from conclusive. None of the evidence specifically implicates MCPA, MCPP, or 2,4-DP as human carcinogens.
Descriptors (primary) herbicides; chloromethylphenoxyacetic acid; carcinogenic effects; agriculture and forestry; dichlorprop
Descriptors (secondary) mecoprop; toxicology; human experiments; epidemiologic study; animal experiments; hazard evaluation
Document type D - Periodical articles
Country / State or ProvinceGermany; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals