| Document ID (ISN) | 61169 |
| CIS number |
93-1937 |
| ISSN - Serial title |
0096-1736 - Journal of Occupational Medicine |
| Year |
1993 |
| Convention or series no. |
|
| Author(s) |
Sessink P.J.M., De Roos J.H.C., Pierik F.H., Anzion R.B.M., Bos R.P. |
| Title |
Occupational exposure of animal caretakers to cyclophosphamide |
| Bibliographic information |
Jan. 1993, Vol.35, No.1, p.47-52. 15 ref. |
| Abstract |
The study examined environmental contamination with cyclophosphamide (CP) in an animal laboratory where mice were injected with this compound. Also studied was the contamination of gloves, sleeve protectors, and masks for personal protection. Analysis of air-circulation system filters revealed amounts of CP corresponding to <0.1-1.0µg/day. Wipe samples taken from different objects and surfaces were also analysed. The presence of CP was not only observed in the room where the mice were housed and treated but also in adjacent rooms (<0.02-44ng/cm2). The gloves used during CP injection were always contaminated (2-199µg/pair), although no penetration was established. The sleeve protectors were incidentally contaminated (<0.3-10µg) and no CP was found on the masks (<0.2µg). Eighty-seven urine samples from four animal caretakers were analysed for unmetabolised CP. CP was detected (0.7µg) in one sample. The results of this study show that animal caretakers are exposed to CP in their work. |
| Descriptors (primary) |
cyclophosphamide; experimental animals; handling of animals; contamination; exposure evaluation |
| Descriptors (secondary) |
protective gloves; rodents; determination in urine; air sampling; clothing contamination |
| Document type |
D - Periodical articles |
| Country / State or Province | Netherlands |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Livestock rearing
Animal hazards
Exposure evaluation
Heterocyclic compounds
|
