|Document ID (ISN)||60845|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Hagmar L., Welinder H., Lindén K., Attewell R., Osterman-Golkar S., Törnqvist M.
||An epidemiological study of cancer risk among workers exposed to ethylene oxide using hemoglobin adducts to validate environmental exposure assessments
||1991, Vol.63, No.4, p.271-277. Illus. 30 ref.
||Cancer morbidity was investigated in a cohort of 2,170 ethylene oxide (EO)-exposed workers from 2 plants producing disposable medical equipment. The subjects had been employed for at least 1 year during the periods 1970-1985 and 1964-1985, respectively. The exposure to EO was assessed for each of six job categories in the plants with respect to each calendar year, on which basis values for individual cumulative exposure to EO (ppm-years) were calculated. The levels of hydroxyethyl adducts to N-terminal valine (HOEtVal) in haemoglobin fitted well with the values estimated for airborne exposure to EO. No increased cancer incidence was found (standardised morbidity ratio (SMR), 0.78; 95% CI, 0.49-1.21). No leukaemia was observed, but one case of non-Hodgkin's lymphoma, one case of myeloma, and one case of polycythaemia vera were diagnosed as compared with two expected haematopoietic and lymphatic tumours (SMR, 1.54; 95% CI, 0.32-4.5). No stomach cancer was detected as compared with the 0.5 case expected. There were no significant exposure-response associations between estimates of exposures to EO and cancer morbidity.
||ethylene oxide; haemic and lymphatic diseases; neoplasms; diseases of blood-forming organs; exposure evaluation
||leukaemia; gastrointestinal cancer; lymphoma
||D - Periodical articles
|Country / State or Province||Sweden|
||Toxic and dangerous substances
|Broad subject area(s)