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Document ID (ISN)60845
CIS number 93-1618
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1991
Convention or series no.
Author(s) Hagmar L., Welinder H., Lindén K., Attewell R., Osterman-Golkar S., Törnqvist M.
Title An epidemiological study of cancer risk among workers exposed to ethylene oxide using hemoglobin adducts to validate environmental exposure assessments
Bibliographic information 1991, Vol.63, No.4, p.271-277. Illus. 30 ref.
Abstract Cancer morbidity was investigated in a cohort of 2,170 ethylene oxide (EO)-exposed workers from 2 plants producing disposable medical equipment. The subjects had been employed for at least 1 year during the periods 1970-1985 and 1964-1985, respectively. The exposure to EO was assessed for each of six job categories in the plants with respect to each calendar year, on which basis values for individual cumulative exposure to EO (ppm-years) were calculated. The levels of hydroxyethyl adducts to N-terminal valine (HOEtVal) in haemoglobin fitted well with the values estimated for airborne exposure to EO. No increased cancer incidence was found (standardised morbidity ratio (SMR), 0.78; 95% CI, 0.49-1.21). No leukaemia was observed, but one case of non-Hodgkin's lymphoma, one case of myeloma, and one case of polycythaemia vera were diagnosed as compared with two expected haematopoietic and lymphatic tumours (SMR, 1.54; 95% CI, 0.32-4.5). No stomach cancer was detected as compared with the 0.5 case expected. There were no significant exposure-response associations between estimates of exposures to EO and cancer morbidity.
Descriptors (primary) ethylene oxide; haemic and lymphatic diseases; neoplasms; diseases of blood-forming organs; exposure evaluation
Descriptors (secondary) leukaemia; gastrointestinal cancer; lymphoma
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Ethylene oxide
Exposure evaluation