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CISDOC database

Document ID (ISN)60741
CIS number 93-1631
ISSN - Serial title Journal of the National Cancer Institute
Year 1992
Convention or series no.
Author(s) Garabrant D.H., Held J., Langholz B., Peters J.M., Mack T.M.
Title DDT and related compounds and risk of pancreatic cancer
Bibliographic information 20 May 1992, Vol.84, No.10, p.764-771. 44 ref.
Abstract To identify risk factors for pancreatic cancer, a nested case-control study of chemical manufacturing workers was conducted using 28 verified cases of pancreatic cancer and 112 matched controls. DDT was associated with pancreatic cancer (risk ratio (RR) for ever exposed compared with never exposed = 4.8; 95% confidence interval = 1.3-17.6). Among subjects who had a mean exposure to DDT of 47 months, the risk was 7.4 times that among subjects with no exposure. Two DDT derivatives, Ethylan and DDD, were additionally associated with pancreatic cancer (RR = 5.0 and 4.3, respectively). Smoking was identified as an independent risk factor, but controlling for it (and other potential confounders) in the analyses did not appreciably alter the risks seen for DDT, DDD, or Ethylan. These results may indicate that DDT can cause pancreatic cancer in humans under circumstances of heavy and prolonged exposure.
Descriptors (primary) perthane; DDT; long-term exposure; tumour of the pancreas; p,p'-ddd
Descriptors (secondary) risk factors; chemical industry
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Halogenated hydrocarbons
Endocrine diseases