|Document ID (ISN)||60741|
|ISSN - Serial title
||Journal of the National Cancer Institute
|Convention or series no.
||Garabrant D.H., Held J., Langholz B., Peters J.M., Mack T.M.
||DDT and related compounds and risk of pancreatic cancer
||20 May 1992, Vol.84, No.10, p.764-771. 44 ref.
||To identify risk factors for pancreatic cancer, a nested case-control study of chemical manufacturing workers was conducted using 28 verified cases of pancreatic cancer and 112 matched controls. DDT was associated with pancreatic cancer (risk ratio (RR) for ever exposed compared with never exposed = 4.8; 95% confidence interval = 1.3-17.6). Among subjects who had a mean exposure to DDT of 47 months, the risk was 7.4 times that among subjects with no exposure. Two DDT derivatives, Ethylan and DDD, were additionally associated with pancreatic cancer (RR = 5.0 and 4.3, respectively). Smoking was identified as an independent risk factor, but controlling for it (and other potential confounders) in the analyses did not appreciably alter the risks seen for DDT, DDD, or Ethylan. These results may indicate that DDT can cause pancreatic cancer in humans under circumstances of heavy and prolonged exposure.
||perthane; DDT; long-term exposure; tumour of the pancreas; p,p'-ddd
||risk factors; chemical industry
||D - Periodical articles
|Country / State or Province||USA|
||Chemicals, plastics and rubber
|Broad subject area(s)