| Document ID (ISN) | 60688 |
| CIS number |
93-1207 |
| ISSN - Serial title |
0096-1736 - Journal of Occupational Medicine |
| Year |
1988 |
| Convention or series no. |
|
| Author(s) |
Sterling T.D., Weinkam J.J. |
| Title |
Reanalysis of lung cancer mortality in a National Cancer Institute study on mortality among industrial workers exposed to formaldehyde; Formaldehyde revisited - Comments on the reanalysis of the N.C.I. study of workers exposed to formaldehyde |
| Bibliographic information |
Nov. 1988, Vol.30, No.11, p.895-901. 23 ref. Comments in same periodical, Nov. 1989, Vol.31, No.11, p.881-884. 5+6 ref. |
| Abstract |
This is a reanalysis of the data from a 1986 study of 26,561 formaldehyde-exposed workers conducted by Blair A. et al (CIS 93-1206). It is suggested that the design and analysis of the original study had possibly masked an existing occupational hazard, possibly as a result of the healthy worker effect. This reanalysis finds a significantly increased risk for all cancers and for lung cancer as a function of cumulative exposure when workers with higher levels of exposure are compared with those with little or no exposure, while simultaneously considering length of exposure. The risk ratio for lung cancer at cumulative exposures of 0.1-0.5ppm is 1.41 (0.95 CI 1.20-1.66), at 0.5-2.0ppm it is 1.73 (1.42-2.11) and at >2.0ppm it is 1.70 (1.32-2.18). The column Formaldehyde revisited in the Nov. 1989 issue of JOM includes further comments by Blair A. and Stewart P.A., on the one hand, and by Weinkam J.J., on the other, concerning the details of the statistical analysis used, and the interpretation of the results. Although both sets of authors accept the existence of excess mortality from lung cancer among formaldehyde-exposed workers, the former (Blair and Stewart) do not think that this excess is due to exposure to formaldehyde. |
| Descriptors (primary) |
formaldehyde; dose-response relationship; lung cancer; mortality |
| Descriptors (secondary) |
healthy worker effect; USA; neoplasms; long-term study; epidemiologic study |
| Document type |
D - Periodical articles |
| Country / State or Province | Canada |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Occupational medicine, epidemiology
|
| Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar)
Aldehydes
|
